My bibliography

I believe research is only really successful when the results are brought back to the clinical field where the findings are able to help children and improve their lives. This is why I am so passionate about research and why I dedicate to it so much of my time.
I have been involved as an investigator in some ground breaking research like a Leducq foundation grant looking at developing tools to better understand single ventricle physiology and the NLHBI-funded Bench to Bassinet project which is producing very significant advancements in the understanding of the genetic causes of congenital cardiac defects. Please see below to know more about my research interests:

Crow Y, Keshavan N, Barbet JP, Bercu G, Bondet V, Boussard C, Dedieu N, Duffy D, Hully M, Giardini A, Gitiaux C, Rice GI, Seabra L, Bader-Meunier B, Rahman S. Cardiac valve involvement in ADAR-related type I interferonopathy. J Med Genet. 2020 Jul;57(7):475-478. doi: 10.1136/jmedgenet-2019-106457. Epub 2019 Nov 26. PubMed PMID: 31772029.
Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma’ayan A, Gelb BD. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic Transl Sci. 2020 Apr;5(4):376-386. doi: 10.1016/j.jacbts.2020.01.012. eCollection 2020 Apr. PubMed PMID: 32368696; PubMed Central PMCID: PMC7188873.
Chen SC, Dastamani A, Pintus D, Yau D, Aftab S, Bath L, Swinburne C, Hunter L, Giardini A, Christov G, Senniappan S, Banerjee I, Shaikh MG, Shah P. Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. Clin Endocrinol (Oxf). 2019 Dec;91(6):770-775. doi: 10.1111/cen.14096. Epub 2019 Oct 1. PubMed PMID: 31520536.
Richter F, Hoffman GE, Manheimer KB, Patel N, Sharp AJ, McKean D, Morton SU, DePalma S, Gorham J, Kitaygorodksy A, Porter GA, Giardini A, Shen Y, Chung WK, Seidman JG, Seidman CE, Schadt EE, Gelb BD. ORE identifies extreme expression effects enriched for rare variants. Bioinformatics. 2019 Oct 15;35(20):3906-3912. doi: 10.1093/bioinformatics/btz202. PubMed PMID: 30903145; PubMed Central PMCID: PMC6792115.
Pant S, Corsini C, Baker C, Hsia TY, Pennati G, Vignon-Clementel IE. A Lumped Parameter Model to Study Atrioventricular Valve Regurgitation in Stage 1 and Changes Across Stage 2 Surgery in Single Ventricle Patients. IEEE Trans Biomed Eng. 2018 Nov;65(11):2450-2458. doi: 10.1109/TBME.2018.2797999. Epub 2018 Jan 25. PubMed PMID: 29993472.
Corsini C, Migliavacca F, Hsia TY, Pennati G. The influence of systemic-to-pulmonary arterial shunts and peripheral vasculatures in univentricular circulations: Focus on coronary perfusion and aortic arch hemodynamics through computational multi-domain modeling. J Biomech. 2018 Oct 5;79:97-104. doi: 10.1016/j.jbiomech.2018.07.042. Epub 2018 Aug 4. PubMed PMID: 30097266.
Solman L, Glover M, Beattie PE, Buckley H, Clark S, Gach JE, Giardini A, Helbling I, Hewitt RJ, Laguda B, Langan SM, Martinez AE, Murphy R, Proudfoot L, Ravenscroft J, Shahidullah H, Shaw L, Syed SB, Wells L, Flohr C. Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology consensus guidelines. Br J Dermatol. 2018 Sep;179(3):582-589. doi: 10.1111/bjd.16779. PubMed PMID: 29774538.
Hoang TT, Goldmuntz E, Roberts AE, Chung WK, Kline JK, Deanfield JE, Giardini A, Aleman A, Gelb BD, Mac Neal M, Porter GA Jr, Kim R, Brueckner M, Lifton RP, Edman S, Woyciechowski S, Mitchell LE, Agopian AJ. The Congenital Heart Disease Genetic Network Study: Cohort description. PLoS One. 2018;13(1):e0191319. doi: 10.1371/journal.pone.0191319. eCollection 2018. PubMed PMID: 29351346; PubMed Central PMCID: PMC5774789.
Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nat Genet. 2017 Nov;49(11):1593-1601. doi: 10.1038/ng.3970. Epub 2017 Oct 9. PubMed PMID: 28991257; PubMed Central PMCID: PMC5675000.
Corsini C, Cervi E, Migliavacca F, Schievano S, Hsia TY, Pennati G. Mathematical modelling of the maternal cardiovascular system in the three stages of pregnancy. Med Eng Phys. 2017 Sep;47:55-63. doi: 10.1016/j.medengphy.2017.06.025. Epub 2017 Jul 8. PubMed PMID: 28694109.
Cutrì E, Meoli A, Dubini G, Migliavacca F, Hsia TY, Pennati G. Patient-specific biomechanical model of hypoplastic left heart to predict post-operative cardio-circulatory behaviour. Med Eng Phys. 2017 Sep;47:85-92. doi: 10.1016/j.medengphy.2017.06.024. Epub 2017 Jul 8. PubMed PMID: 28698113.
Schiavazzi DE, Baretta A, Pennati G, Hsia TY, Marsden AL. Patient-specific parameter estimation in single-ventricle lumped circulation models under uncertainty. Int J Numer Method Biomed Eng. 2017 Mar;33(3). doi: 10.1002/cnm.2799. Epub 2016 Jun 8. PubMed PMID: 27155892; PubMed Central PMCID: PMC5499984.
Bruse JL, Khushnood A, McLeod K, Biglino G, Sermesant M, Pennec X, Taylor AM, Hsia TY, Schievano S. How successful is successful? Aortic arch shape after successful aortic coarctation repair correlates with left ventricular function. J Thorac Cardiovasc Surg. 2017 Feb;153(2):418-427. doi: 10.1016/j.jtcvs.2016.09.018. Epub 2016 Sep 22. PubMed PMID: 27776913.
Bruse JL, Cervi E, McLeod K, Biglino G, Sermesant M, Pennec X, Taylor AM, Schievano S, Hsia TY. Looks Do Matter! Aortic Arch Shape After Hypoplastic Left Heart Syndrome Palliation Correlates With Cavopulmonary Outcomes. Ann Thorac Surg. 2017 Feb;103(2):645-654. doi: 10.1016/j.athoracsur.2016.06.041. Epub 2016 Sep 1. PubMed PMID: 27592606.
Pant S, Corsini C, Baker C, Hsia TY, Pennati G, Vignon-Clementel IE. Inverse problems in reduced order models of cardiovascular haemodynamics: aspects of data assimilation and heart rate variability. J R Soc Interface. 2017 Jan;14(126). doi: 10.1098/rsif.2016.0513. PubMed PMID: 28077762; PubMed Central PMCID: PMC5310725
Abumehdi MR, Wardle AJ, Nazzal R, Charalampopoulos A, Schulze-Neick I, Derrick G, Moledina S, Giardini A. Feasibility and safety of cardiopulmonary exercise testing in children with pulmonary hypertension. Cardiol Young. 2016 Aug;26(6):1144-50. doi: 10.1017/S1047951115001961. Epub 2015 Sep 16. PubMed PMID: 26374593
Pant S, Corsini C, Baker C, Hsia TY, Pennati G, Vignon-Clementel IE. Data assimilation and modelling of patient-specific single-ventricle physiology with and without valve regurgitation. J Biomech. 2016 Jul 26;49(11):2162-2173. doi: 10.1016/j.jbiomech.2015.11.030. Epub 2015 Nov 28. PubMed PMID: 26708918.
Bruse JL, McLeod K, Biglino G, Ntsinjana HN, Capelli C, Hsia TY, Sermesant M, Pennec X, Taylor AM, Schievano S. A statistical shape modelling framework to extract 3D shape biomarkers from medical imaging data: assessing arch morphology of repaired coarctation of the aorta. BMC Med Imaging. 2016 May 31;16(1):40. doi: 10.1186/s12880-016-0142-z. PubMed PMID: 27245048; PubMed Central PMCID: PMC4894556
Hang T, Giardini A, Biglino G, Conover T, Figliola RS. In Vitro Validation of a Multiscale Patient-Specific Norwood Palliation Model. ASAIO J. 2016 May-Jun;62(3):317-24. doi: 10.1097/MAT.0000000000000336. PubMed PMID: 26771396.
Arbia G, Corsini C, Baker C, Pennati G, Hsia TY, Vignon-Clementel IE. Erratum to: Pulmonary Hemodynamics Simulations Before Stage 2 Single Ventricle Surgery: Patient-Specific Parameter Identification and Clinical Data Assessment. Cardiovasc Eng Technol. 2016 Mar;7(1):102. doi: 10.1007/s13239-015-0248-4. PubMed PMID: 26906194.
Schiavazzi DE, Arbia G, Baker C, Hlavacek AM, Hsia TY, Marsden AL, Vignon-Clementel IE. Uncertainty quantification in virtual surgery hemodynamics predictions for single ventricle palliation. Int J Numer Method Biomed Eng. 2016 Mar;32(3):e02737. doi: 10.1002/cnm.2737. Epub 2015 Sep 2. PubMed PMID: 26217878.
Petrini L, Trotta A, Dordoni E, Migliavacca F, Dubini G, Lawford PV, Gosai JN, Ryan DM, Testi D, Pennati G. A Computational Approach for the Prediction of Fatigue Behaviour in Peripheral Stents: Application to a Clinical Case. Ann Biomed Eng. 2016 Feb;44(2):536-47. doi: 10.1007/s10439-015-1472-7. Epub 2015 Oct 3. Review. PubMed PMID: 26433586.
Hsia TY, Figliola R. Multiscale modelling of single-ventricle hearts for clinical decision support: a Leducq Transatlantic Network of Excellence. Eur J Cardiothorac Surg. 2016 Feb;49(2):365-8. doi: 10.1093/ejcts/ezv368. Epub 2015 Oct 21. PubMed PMID: 26489838.
Biglino G, Cosentino D, Steeden JA, De Nova L, Castelli M, Ntsinjana H, Pennati G, Taylor AM, Schievano S. Using 4D Cardiovascular Magnetic Resonance Imaging to Validate Computational Fluid Dynamics: A Case Study. Front Pediatr. 2015;3:107. doi: 10.3389/fped.2015.00107. eCollection 2015. PubMed PMID: 26697416; PubMed Central PMCID: PMC4677094.
Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 4;350(6265):1262-6. doi: 10.1126/science.aac9396. PubMed PMID: 26785492; PubMed Central PMCID: PMC4890146.
Müller J, Hager A, Diller GP, Derrick G, Buys R, Dubowy KO, Takken T, Orwat S, Inuzuka R, Vanhees L, Gatzoulis M, Giardini A. Peak oxygen uptake, ventilatory efficiency and QRS-duration predict event free survival in patients late after surgical repair of tetralogy of Fallot. Int J Cardiol. 2015 Oct 1;196:158-64. doi: 10.1016/j.ijcard.2015.05.174. Epub 2015 Jun 2. PubMed PMID: 26114442.
Arbia G, Corsini C, Baker C, Pennati G, Hsia TY, Vignon-Clementel IE. Pulmonary Hemodynamics Simulations Before Stage 2 Single Ventricle Surgery: Patient-Specific Parameter Identification and Clinical Data Assessment. Cardiovasc Eng Technol. 2015 Sep;6(3):268-80. doi: 10.1007/s13239-015-0212-3. Epub 2015 Jan 22. PubMed PMID: 26577360.
Corsini C, Baker C, Baretta A, Biglino G, Hlavacek AM, Hsia TY, Kung E, Marsden A, Migliavacca F, Vignon-Clementel I, Pennati G. Integration of clinical data collected at different times for virtual surgery in single ventricle patients: a case study. Ann Biomed Eng. 2015 Jun;43(6):1310-20. doi: 10.1007/s10439-014-1113-6. Epub 2014 Oct 25. PubMed PMID: 25344350.
Kung E, Perry JC, Davis C, Migliavacca F, Pennati G, Giardini A, Hsia TY, Marsden A. Computational modeling of pathophysiologic responses to exercise in Fontan patients. Ann Biomed Eng. 2015 Jun;43(6):1335-47. doi: 10.1007/s10439-014-1131-4. Epub 2014 Sep 27. PubMed PMID: 25260878; PubMed Central PMCID: PMC4376649.
Biglino G, Capelli C, Wray J, Schievano S, Leaver LK, Khambadkone S, Giardini A, Derrick G, Jones A, Taylor AM. 3D-manufactured patient-specific models of congenital heart defects for communication in clinical practice: feasibility and acceptability. BMJ Open. 2015 Apr 30;5(4):e007165. doi: 10.1136/bmjopen-2014-007165. PubMed PMID: 25933810; PubMed Central PMCID: PMC4420970.
Meoli A, Cutrì E, Krishnamurthy A, Dubini G, Migliavacca F, Hsia TY, Pennati G, Taylor A, Giardini A, Khambadkone S, Schievano S, de Leval M, Hsia TY, Bove E, Dorfman A, Baker GH, Hlavacek A, Migliavacca F, Pennati G, Dubini G, Marsden A, Feinstein J, Vignon-Clementel I, Figliola R, McGregor J. A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case. Interface Focus. 2015 Apr 6;5(2):20140079. doi: 10.1098/rsfs.2014.0079. PubMed PMID: 25844151; PubMed Central PMCID: PMC4342947.
Ibrahim M, Tsang VT, Caruana M, Hughes ML, Jenkyns S, Perdreau E, Giardini A, Marek J. Cone reconstruction for Ebstein’s anomaly: Patient outcomes, biventricular function, and cardiopulmonary exercise capacity. J Thorac Cardiovasc Surg. 2015 Apr;149(4):1144-50. doi: 10.1016/j.jtcvs.2014.12.074. Epub 2015 Jan 12. PubMed PMID: 25702323
Kung E, Marsden A, Baker C, Giardini A, Figliola R, Hsia TY. Does TCPC power loss really affect exercise capacity?. Heart. 2015 Apr;101(7):575. doi: 10.1136/heartjnl-2014-307379. Epub 2015 Jan 13. PubMed PMID: 25586155.
Ciliberti P, McLeod I, Cairello F, Kaski JP, Fenton M, Giardini A, Marek J. Semi-supine exercise stress echocardiography in children and adolescents: feasibility and safety. Pediatr Cardiol. 2015 Mar;36(3):633-9. doi: 10.1007/s00246-014-1058-4. Epub 2014 Nov 20. PubMed PMID: 25410823; PubMed Central PMCID: PMC4335126.
Schiavazzi DE, Kung EO, Marsden AL, Baker C, Pennati G, Hsia TY, Hlavacek A, Dorfman AL. Hemodynamic effects of left pulmonary artery stenosis after superior cavopulmonary connection: a patient-specific multiscale modeling study. J Thorac Cardiovasc Surg. 2015 Mar;149(3):689-96.e1-3. doi: 10.1016/j.jtcvs.2014.12.040. Epub 2014 Dec 20. PubMed PMID: 25659189.
Esmaily-Moghadam M, Hsia TY, Marsden AL. The assisted bidirectional Glenn: a novel surgical approach for first-stage single-ventricle heart palliation. J Thorac Cardiovasc Surg. 2015 Mar;149(3):699-705. doi: 10.1016/j.jtcvs.2014.10.035. Epub 2014 Oct 15. PubMed PMID: 25454920; PubMed Central PMCID: PMC6089632.
Esmaily-Moghadam M, Murtuza B, Hsia TY, Marsden A. Simulations reveal adverse hemodynamics in patients with multiple systemic to pulmonary shunts. J Biomech Eng. 2015 Mar;137(3). doi: 10.1115/1.4029429. Epub 2015 Jan 29. PubMed PMID: 25531794; PubMed Central PMCID: PMC4321115.
Plymen CM, Finlay M, Tsang V, O’leary J, Picaut N, Cullen S, Walker F, Deanfield JE, Hsia TY, Bolger AP, Lambiase PD. Haemodynamic consequences of targeted single- and dual-site right ventricular pacing in adults with congenital heart disease undergoing surgical pulmonary valve replacement. Europace. 2015 Feb;17(2):274-80. doi: 10.1093/europace/euu281. Epub 2014 Nov 4. PubMed PMID: 25371427; PubMed Central PMCID: PMC4309992.
Salam S, Dominguez T, Tsang V, Giardini A. Longer hospital stay after Fontan completion in the November to March period. Eur J Cardiothorac Surg. 2015 Feb;47(2):262-8. doi: 10.1093/ejcts/ezu134. Epub 2014 Mar 28. PubMed PMID: 24682870.
Butts RJ, Chowdhury SM, Buckley J, Hlavacek AM, Hsia TY, Khambadkone S, Baker GH. Comparison of echocardiographic and pressure-volume loop indices of systolic function in patients with single ventricle physiology: a preliminary report. Congenit Heart Dis. 2015 Jan-Feb;10(1):E17-24. doi: 10.1111/chd.12191. Epub 2014 May 28. PubMed PMID: 24869911; PubMed Central PMCID: PMC4373647.
Biglino G, Ntsinjana H, Plymen C, Tann O, Giardini A, Derrick G, Parker KH, Tsang V, Schievano S, Taylor AM. Ventriculovascular interactions late after atrial and arterial repair of transposition of the great arteries. J Thorac Cardiovasc Surg. 2014 Dec;148(6):2627-33. doi: 10.1016/j.jtcvs.2014.07.072. Epub 2014 Aug 5. PubMed PMID: 25224549.
Lurz P, Riede FT, Taylor AM, Wagner R, Nordmeyer J, Khambadkone S, Kinzel P, Derrick G, Schuler G, Bonhoeffer P, Giardini A, Daehnert I. Impact of percutaneous pulmonary valve implantation for right ventricular outflow tract dysfunction on exercise recovery kinetics. Int J Cardiol. 2014 Nov 15;177(1):276-80. doi: 10.1016/j.ijcard.2014.09.014. Epub 2014 Sep 22. PubMed PMID: 25499392.
Biglino G, Giardini A, Ntsinjana HN, Schievano S, Hsia TY, Taylor AM. Ventriculoarterial coupling in palliated hypoplastic left heart syndrome: Noninvasive assessment of the effects of surgical arch reconstruction and shunt type. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1526-33. doi: 10.1016/j.jtcvs.2014.02.012. Epub 2014 Feb 10. PubMed PMID: 24629219.
Giardini A, Cervi E. Asymptomatic adults with mild/moderate isolated native pulmonary valve stenosis are in need of treatment… but not the kind you are thinking of!. Heart. 2014 Sep;100(17):1313-4. doi: 10.1136/heartjnl-2014-306012. Epub 2014 Jun 26. PubMed PMID: 24968883.
Chowdhury SM, Butts RJ, Buckley J, Hlavacek AM, Hsia TY, Khambadkone S, Baker GH. Comparison of pressure-volume loop and echocardiographic measures of diastolic function in patients with a single-ventricle physiology. Pediatr Cardiol. 2014 Aug;35(6):998-1006. doi: 10.1007/s00246-014-0888-4. Epub 2014 Mar 2. PubMed PMID: 24584211; PubMed Central PMCID: PMC4082737.
Corsini C, Biglino G, Schievano S, Hsia TY, Migliavacca F, Pennati G, Taylor AM. The effect of modified Blalock-Taussig shunt size and coarctation severity on coronary perfusion after the Norwood operation. Ann Thorac Surg. 2014 Aug;98(2):648-54. doi: 10.1016/j.athoracsur.2014.04.047. Epub 2014 Jun 4. PubMed PMID: 24906601.
Kung E, Pennati G, Migliavacca F, Hsia TY, Figliola R, Marsden A, Giardini A. A simulation protocol for exercise physiology in Fontan patients using a closed loop lumped-parameter model. J Biomech Eng. 2014 Aug;136(8). doi: 10.1115/1.4027271. PubMed PMID: 24658635; PubMed Central PMCID: PMC5101033.
Vukicevic M, Conover T, Jaeggli M, Zhou J, Pennati G, Hsia TY, Figliola RS. Control of respiration-driven retrograde flow in the subdiaphragmatic venous return of the Fontan circulation. ASAIO J. 2014 Jul-Aug;60(4):391-9. doi: 10.1097/MAT.0000000000000093. PubMed PMID: 24814833; PubMed Central PMCID: PMC4225011.
Biglino G, Corsini C, Schievano S, Dubini G, Giardini A, Hsia TY, Pennati G, Taylor AM. Computational models of aortic coarctation in hypoplastic left heart syndrome: considerations on validation of a detailed 3D model. Int J Artif Organs. 2014 May;37(5):371-81. doi: 10.5301/ijao.5000332. Epub 2014 May 30. PubMed PMID: 24968194.
Corsini C, Baker C, Kung E, Schievano S, Arbia G, Baretta A, Biglino G, Migliavacca F, Dubini G, Pennati G, Marsden A, Vignon-Clementel I, Taylor A, Hsia TY, Dorfman A. An integrated approach to patient-specific predictive modeling for single ventricle heart palliation. Comput Methods Biomech Biomed Engin. 2014;17(14):1572-89. doi: 10.1080/10255842.2012.758254. Epub 2013 Jan 23. PubMed PMID: 23343002; PubMed Central PMCID: PMC4242799.